Objective: To explore the association between the duration and frequency of napping and the incidence of angina pectoris (AP). Methods: A total of 2,269 subjects from the Sleep Heart Health Study were selected. Baseline data and napping habits (duration and frequency) were collected. The first diagnosed cases of angina pectoris during an average follow-up period of 11 years were recorded. Logistic regression analysis was used to evaluate the correlation between napping duration and frequency and the incidence of angina pectoris. Results: Significant differences were observed among groups with different napping frequencies (0 times/week, 1–2 times/week, 3–4 times/week, and ≥5 times/week) and durations (0 minutes, <30 minutes, and ≥30 minutes) in terms of gender, age, body mass index (BMI), alcohol consumption, blood lipid levels (total cholesterol, high-density lipoprotein, triglycerides), diabetes, hypertension, and angina pectoris (P<0.05). After adjusting for confounding factors, the study found that napping habits of ≥5 times/week (OR=1.65, 95%CI=1.27–2.14, P<0.001) and ≥30 minutes (OR=1.92, 95%CI=1.41–2.61, P<0.001) were independently associated with an increased prevalence of angina pectoris. In different subgroups, the association between napping frequency and angina pectoris was more significant in the population aged <60 years (P interaction=0.009), while no significant interaction effect was observed in other subgroup analyses.