1 Clinical Data Case 1: A 45-year-old female presented in June 2014 with a 1-year history of pain in the left neck and shoulder. Physical examination revealed mild neck rigidity, slight tenderness over the left neck and shoulder, and exacerbated pain upon neck rotation. Plain cervical computed tomography (CT) (Figure 1A) showed an irregular soft-tissue density lesion medial to the carotid sheath (from the oropharynx to the C6 vertebral body), with a maximum cross-sectional area of 3.0 cm × 5.8 cm. The lesion had ill-defined borders with the surrounding fat space, and multiple osteolytic lesions were observed in the C3–C5 vertebral bodies. Posterior pharyngeal tumor resection via a lateral cervical approach was performed on June 12, 2014. Intraoperatively, a large mass measuring approximately 5 cm × 2.5 cm × 2 cm was found anterior to the left C3–C5 vertebral bodies. The mass was hard in texture with unclear boundaries, and the cut surface appeared fish-flesh-like. Postoperative pathological diagnosis: chordoma. Immunohistochemistry results: S-100 (+), CK (+), EMA (+), PR (?), GFAP (?), vimentin (+), Ki-67 (+, 1%), syn (?), CD56 (+). The findings were consistent with the diagnosis of chordoma.