Objective:To investigate the value of peripheral blood eosinophil(EOS)count and fractional exhaled nitric oxide(FeNO)in the diagnosis and management of children with cough variant asthma(CVA). Methods:60 children with CVA were included in the CVA group,and 60 children with non-CVA chronic cough treated in the hospital during the same period were selected as the cough group.After 4 weeks of treatment,the children with CVA were divided into well-controlled group(n=30),partially controlled group (n=18)and uncontrolled group (n=12)according to the control status of children’s asthma control test.The baseline data,FeNO and EOS count were compared in children with CVA group,cough group,and different asthma control groups.The value of EOS count and FeNO in the diagnosis and management of CVA in children was analyzed by receiver operating characteristic (ROC)curve. Results:The percentage of predicted value for forced expiratory volume in one second(FEV1%Pred),percentage of predicted value for peak expiratory flow (PEF%pred)and percentage of predicted value for forced expiratory flow at 50% (FEF50%pred)in the CVA group were lower than those in the cough group(P<0.05),while the FeNO,EOS count and immunoglobulin E (IgE)were higher compared to the cough group(P<0.05). ROC curve revealed that the areas under the curves of FeNO and EOS count in the diagnosis of CVA children were 0.912(95% CI:0.853~0.970)and 0.876(95% CI:0.810~0.942),and the sensitivities were 90.00%and 83.30%,and the specificities were 90.00% and 88.30%,respectively. FeNO,EOS count and IgE were lower in the well-controlled group than those in the partially controlled group and the uncontrolled group (P<0.05),and were also lower in the partially controlled group than those in the uncontrolled group(P<0.05). ROC curve suggested that the areas under the curves of FeNO and EOS count were 0.898(95% CI:0.786~1.000)and 0.806(95% CI:0.667~0.944)in the evaluation of good control of CVA in children,and the sensitivities were 83.30% and 77.80%,and the specificities were 96.70% and 73.30%,respectively. Conclusion:EOS count and FeNO level in children with CVA are increased,and EOS count and FeNO have high value in the diagnosis and management of CVA in children.