Objective: To explore the application effect of evidence-based nursing model based on risk defense mechanism on reducing risks during laparoscopic hysterectomy. Methods: A total of 92 patients undergoing laparoscopic hysterectomy were enrolled. Patients were divided into a conventional intervention group and an evidence-based intervention group based on different intervention methods, with 46 cases in each group. The perioperative indicators, negative emotions and quality of life (GQOLI-74) before and after nursing, incidence rates of perioperative adverse events and complaints, and patient satisfaction were compared between the two groups. Results: The gastrointestinal function recovery time, ambulation time and hospitalization time in evidence-based intervention group were shorter than those in conventional intervention group (P < 0.05). After nursing, the SAS score and SDS score in the two groups were decreased (P<0.05), and the scores in evidence-based intervention group were lower than those in conventional intervention group(P<0.05). The scores of GQOLI-74 items in evidence-based intervention group were higher than those in conventional intervention group(P<0.05). The incidence rates of adverse events were lower in evidence-based intervention group than those in conventional intervention group(P<0.05), and the nursing complaint rate was also lower than that in conventional intervention group(P<0.05). The nursing satisfaction in evidence-based intervention group was higher compared to conventional intervention group (P<0.05). Conclusion: Evidence-based intervention model based on risk defense mechanism can effectively promote the postoperative rehabilitation of patients with laparoscopic hysterectomy, improve the negative emotions and living standards, and reduce perioperative adverse events and complaint rate. It has high patient satisfaction and is worthy of clinical promotion and use.