Objective: To investigate the efficacy of Fuyang cupping therapy combined with western medicine in the treatment of chronic pelvic pain secondary to sequelae of pelvic inflammatory disease (SPID-CPP). Methods: A total of 100 SPID-CPP patients were selected and divided into two groups according to different treatment options, 50 cases in each group. The control group was managed with oral ibuprofen. On this basis, the observation group received supplementary Fuyang cupping sessions. Both groups received treatment for 3 menstrual cycles. The scores of pain score (lower abdominal pain, lumbosacral pain), local sign score, the TCM syndrome scores and quality of life scores were compared between the two groups. Serum inflammatory factors [hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6)] and hemorheology indexes [erythrocyte sedimentation rate (ESR), fibrinogen (Fib), plasma viscosity] were detected in both groups, and the efficacy and incidence of adverse reactions were assessed in each of the two groups. Results: The total effective rate was higher in the observation group than that in the control group (P<0.05). Post-treatment assessments revealed that the observation group had reduced lower abdominal pain, lumbosacral pain, local sign, and TCM syndrome scores relative to the control group (P<0.05), while their quality of life score was elevated (P<0.05). After treatment, the levels of serum hs-CRP, IL-6, ESR, Fib and plasma viscosity in the observation group were lower than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Fuyang cupping therapy assisted with western medicine exerts a significant efficacy in the treatment of SPID-CPP. It can more effectively alleviate pain, improve local symptoms, and its underlying mechanism may be related to reducing inflammation and improving hemorheology.