Objective: To explore the effects of ezetimibe combined with rosuvastatin on efficacy, blood lipids, limb motor function in elderly patients with intracranial atherosclerosis (ICA) caused ischemic stroke. Methods: A total of 190 elderly patients with ICA caused ischemic stroke were selected as the research subjects. According to treatment methods, the patients were divided into control group and observation group, with 95 cases in each group. The patients of control group were treated with rosuvastatin, and observation group was treated with ezetimibe on the basis of the control group. The patients of two groups received continuous treatment for 6 months. The efficacy \[modified rankin scale (mRS), national institutes of health stroke scale(NIHSS)\], blood lipids\[total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein-associated phospholipase A2 (Lp-PLA2)\], limb motor function \[Fugl-Meyer motor assessment(FMA) score, activities of daily living(ADL) score\], and adverse reactions of two groups were compared. Results: After treatment, the mRS and NIHSS scores of observation group were both lower than those of the control group(P<0.05). After treatment, the TG, TC, LDL-C, and Lp-PLA2 of the observation group were decreased compared with control group(P<0.05). After treatment, the FMA upper and lower limb motor scores and ADL scores in the observation group were increased compared with control group (P <0.05). There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05). Conclusion: The combination of ezetimibe and rosuvastatin improved neurological function and reduced blood lipid levels in elderly patients with ICA caused ischemic stroke. The combination therapy improved the patients’ limb motor function and daily living ability.