Objective: To explore the effect of combining norepinephrine bitartrate with ulinastatin on patients with septic shock and the improvement role on hemodynamics and cardiac function. Methods: According to different treatment methods, 91 patients with septic shock were divided into observation group (ulinastatin combined with norepinephrine bitartrate, n=47) and control group (norepinephrine bitartrate, n=44). Both groups were treated continuously for 7 days and followed up for 28 days. Prognosis indexes, disease severity, coagulation-inflammation indexes, cardiac function parameters, hemodynamic parameters and adverse reactions were compared between the two groups. Results: No obvious differences in 28-day mortality rate and antibiotic use time were found between groups(P>0.05), and the durations of key measures (vasoactive drug and mechanical ventilation) and ICU stay were shorter in observation group compared to control group(P<0.05), and the disease severity scores, coagulation-inflammation indexes, cardiac function and hemodynamic parameters were better(P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P >0.05). Conclusion: Ulinastatin combined with norepinephrine bitartrate for patients with septic shock can help to enhance blood flow status and cardiac function, regulate inflammation and coagulation status, and shorten the treatment time, with good safety