Objective:To explore the efficacy of holmium laser enucleation of the prostate(HoLEP)in the treatment of benign prostatic hyperplasia(BPH)and the influence on serum prostate specific antigen(PSA)and erectile function of patients.Methods:A total of 98 BPH patients were selected as the study subjects,and they were divided into HoLEP group and TURP group according to dif-ferent surgical treatment methods,with 49 cases in each group.HoLEP group were treated with HoLEP,and TURP group were treated with TURP.The perioperative related indicators(surgical time,bleeding volume,catheterization time,bladder flushing time,and hospital stay),clinical efficacy,serum PSA level,erectile function[International Index of Erectile Function(IIEF-5)],urodynamic parameters[maximum urinary flow rate(Qmax),post voiding residual urine volume(PVR)]and incidence rates of complications were compared between the two groups.Results:The surgical time,bleeding volume,catheterization time,bladder flushing time,and hospital stay in Ho-LEP group were shorter or less than those in TURP group(P＜0.05).At 6 months after surgery,the total clinical efficacy was higher in HoLEP group than that in TURP group(P＜0.05).The PSA level and PVR in the two groups were decreased(P＜0.05),and the in-dicators in HoLEP group were lower than those in TURP group(P＜0.05).The IIEF-5 scores were declined in both groups(P＜0.05),and the HoLEP group had higher scores than the TURP group(P＜0.05).The Qmax in both groups was risen(P＜0.05),and the HoLEP group had higher Qmax(P＜0.05).The incidence rates of complications in HoLEP group were lower compared to TURP group(P＜0.05).Conclusion:HoLEP can enhance the clinical efficacy of patients with BPH,and can protect e-rectile function,and reduce PSA level and incidence rates of complications.