Objective:To analyze and explore the correlation between serum homocysteine(Hcy),serum amyloid A(SAA),low/high-density lipoprotein cholesterol(LDL//HDL)and carotid plaques,prognosis in patients with acute cerebral infarction.Meth-ods:According to stability of carotid plaques,102 patients with acute cerebral infarction were divided into stable group(n=64)and unstable group(n=38).The peripheral blood indicators(Hcy,SAA and LDL/HDL),and carotid plaque stability(vulnerability scores)in the two groups were compared,and their correlation was analyzed.According to prognosis,patients were divided into good prognosis group(n=57)and poor prognosis group(n=45).The peripheral blood indicators(Hcy,SAA and LDL/HDL)were com-pared between the two groups,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of peripheral blood indicators on patient prognosis.Results:Hcy,SAA,LDL/HDL levels and vulnerability scores in stable group were lower than those in unstable group(P＜0.05).Spearman correlation analysis showed that the stability of carotid plaques was positively correlated with Hcy,SAA and LDL/HDL levels(P＜0.05).The levels of Hcy,SAA and LDL/HDL in good prognosis group were lower than those in poor prognosis group(P＜0.05).ROC curves analysis showed that area under the curve(AUC)values of Hcy,SAA and LDL/HDL for predicting prognosis were 0.788,0.796 and 0.676,respectively(P＜0.05).Conclusion:The levels of Hcy,SAA and LDL/HDL are correlated with the stability of carotid plaques in patients with acute cerebral infarction,which also have predictive value in prognosis.