Objective:To investigate the therapeutic effect and mechanism analysis of nimergoline combined with transcutaneous auricular vagus nerve stimulation(taVNS)in the treatment of post-stroke cognitive impairment(PSCI).Methods:104 PSCI patients were selected as the study subjects and divided into a research group(n=52)and a control group(n=52)according to different treatment methods.The control group was given a conventional treatment plan,while the observation group was given a combination of nimergoline and taVNS on the basis of the control group.After 4 weeks of intervention,the levels of cognitive function,neurological func-tion,neurotransmitters,and inflammatory factors were compared between the two groups of patients.Results:After 4 weeks of interven-tion,compared with the control group,the research group showed an increase in MoCA scores in all dimensions(P＜0.05),a decrease in NIHSS scores,neuron-specific enolase(NSE)and S100 calcium binding protein β(S100β)levels(P＜0.05),an increase in ser-um 5-hydroxytryptamine(5-HT),dopamine(DA),and norepin ephrine(NE)levels(P＜0.05),and a decrease in serum interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels(P＜0.05).Conclusion:The combination of nimergo-line and taVNS has a definite therapeutic effect on PSCI,and it is speculated that its mechanism of action may be related to improving the levels of neurotransmitters and inflammatory factors.