Objective:To investigate the correlation of serum thyroid hormones and cortisol(COR)levels with clinical symp-toms in patients with paranoid schizophrenia.Methods:110 patients with paranoid schizophrenia were divided into positive group(n=55)and negative group(n=55)according to the clinical symptoms.In addition,55 healthy people who received physical examination during the same period were included in the control group.Positive and Negative Symptom Scale(PANSS)scores were evaluated and serum thyroid hormones[thyroid stimulating hormone(TSH),free thyroxine(FT4)and free triiodothyronine(FT3)]and COR were detected in the three groups of subjects,and the PANSS scores and levels of thyroid hormones and COR were compared.Pearson correla-tion analysis was used to analyze the correlation between thyroid hormones,COR and PANSS scores in positive group and negative group.Results:The scores of subscales and total score of PANSS in positive and negative groups were higher than those in control group(P＜0.05).The scores of positive symptom and general psychopathological symptom in positive group were higher than those in nega-tive group(P＜0.05)while the score of negative symptom was lower than that in negative group(P＜0.05).TSH level in positive and negative groups was lower(P＜0.05)while FT4,FT3 and COR levels were higher than those in control group(P＜0.05).TSH level in positive group was lower than that in negative group(P＜0.05),but FT4 and FT3 levels were not significantly different from those in negative group(P＞0.05),and COR level was higher than that in negative group(P＜0.05).TSH level in positive group was nega-tively correlated with positive symptom score(P＜0.05),TSH level in negative group was negatively correlated with negative symptom score(P＜0.05),and TSH level in positive and negative groups was negatively corr-elated with general psychopathological symptom score and total score of PANSS(P＜0.05).COR level in positive group was positively correlated with positive symptom score,general psychopathological symptom score and PANSS total score(P＜0.05).Conclusion:Patients with paranoid schizophrenia have abnormal thyroid function and stress function,and the abnormal stress function of patients with positive symptom is more obvious,and serum TSH and COR levels are related to the clinical symptoms of patients.