Objective;To explore the clinical curative effect of cefoperazone sulbactam sodium(CPZ-SBT)combined with mero-penem in children with severe pneumonia induced by bacterial infection.Methods:108 children with severe pneumonia induced by bac-terial infection were selected as the research subjects.According to different treatment methods,children were divided into control group(CPZ-SBT)and combination group(CPZ-SBT combined with meropenem),54 cases in each group.The course of treatment was 7 days.The curative effect,fading time of symptoms,bacterial clearance rates,scores of critical illness(PICS score and APACHE Ⅱscore),T cell subsets(CD4+T cells,CD8+T cells,and CD4+/CD8+T),inflammatory factors[C-reactive protein(CRP),procalcito-nin(PCT),soluble intercellular adhesion molecule-1(sICAM-1)]and adverse drug reactions were compared between the two groups.Results:Compared with control group,response rate of treatment was higher in combination group(P＜0.05),antipyretic time,remis-sion time of cough and disappearance time of moist rale were shorter(P＜0.05),bacterial clearance rate was higher(P＜0.05).cough score was higher(P＜0.05),and PICS score and APACHE Ⅱ score were lower(P＜0.05).The levels of CD4+T cells and CD4+/CD8+ratio in combination group were higher than those in control group,while the levels of CD8+T cells was lower in combina-tion group(P＜0.05).The levels of CRP,PCT and sICAM-1 in combination group were lower than those in control group(P＜0.05).The difference in the total incidence of adverse reactions between combination group and control group was not statistically significant(P＞0.05).Conclusion:Curative effect of CPZ-SBT combined with meropenem is significant in children with severe pneumonia induced by bacterial infection,which can effectively clear infectious bacteria,enhance immune function and relieve inflammatory response.