Objective;To observe the curative effect of dapagliflozin tablet(Farxiga)combined with irbesartan(ARB)in pa-tients with early type 2 diabetic nephropathy.Methods:According to different treatment methods,110 patients with early type 2 diabet-ic nephropathy were divided into ARB group(n=52)and combination group(n=58).All patients were treated for 2 months.After treatment,curative effect,fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),24 h urinary protein(24 h-PRO),uri-nary microalbumin(U-mAlb),thrombin time(TT),activated partial thromboplastin time(aPTT),D-dimer,plasma protein c(PC)and incidence of adverse reactions were compared between the two groups.Results;After treatment,response rate of treatment was high-er in combination group than ARB group(P＜0.05).After treatment,levels of FPG,2 hPG,24 h-PRO,U-mAlb,D-dimer and PC were lower in combination group than ARB group,while TT and aPTT were higher in combination group(P＜0.05).After treatment,the difference in the total incidence of adverse reactions between the two groups was not statistically significant(P＞0.05).Conclusion;Dapagliflozin tablet combined with irbesartan can improve response rate of treatment,reduce blood glucose,urinary protein and improve coagulation function in patients with early type 2 diabetic nephropathy.