Objective:To explore the impact of comprehensive nursing care on the postpartum role adaptability and breastfeeding status of women with high-risk pregnancy for mother-infant separation.Methods:74 high-risk pregnant women with mother infant sepa-ration were divided into two groups based on nursing methods.The control group(n=37)received routine care,while the observation group(n=37)received comprehensive care.The role adaptation ability,initial lactation time,7-day milk production,breastfeeding,and breast swelling were compared between the two groups.Results:Before nursing,there was no statistically significant difference in the scores of role adaptation ability between the two groups(P＞0.05).After nursing,both groups showed an increase in various scores of role adaptation ability,the observation group was higher than the control group(P＜0.05).The observation group had a shorter initial lactation time,and the number of cases with sufficient lactation within 7 days was higher than that of the control group(P＜0.05).The observation group had a higher breastfeeding rate compared to the control group(P＜0.05).Comparison of postpartum breast swelling and pain levels between two groups of mothers,with the observation group had a higher proportion of grade Ⅰ and Ⅱ compared to the con-trol group(P＞0.05).Conclusion:Comprehensive nursing has significant advantages in postpartum care for mothers with high-risk pregnancy.It can more comprehensively meet the multi-faceted needs of mothers,improve their role adaptability,and promote the suc-cess rate of breastfeeding.It is worthy of promotion and application.