Objective:To explore the efficacy of Guizhi Fuling capsule combined with dinogest(DNG)in the treatment of endo-metriosis(EMT)and influence on levels of platelet activating factor(PAF)and transforming growth factor-β1(TGF-β1)in patients with EMT.Methods:98 patients with EMT were retrospectively studied.According to different treatment methods,they were divided into DNG group(n=45,DNG treatment)and combined group(n=53,Guizhi Fuling capsule combined with DNG treatment).The clinical efficacy after 3 menstrual cycles of treatment and TCM syndromes scores,PAF and TGF-β1,hemorheology,hemodynamic indicators and visual analogue scale(VAS)score before and after treatment were compared between groups.Results:After treatment,the efficacy in combined group was better than that in DNG group(P＜0.05).The TCM syndromes scores,PAF,TGF-β1,plasma viscosity,hemato-crit,erythrocyte sedimentation rate and VAS score in the two groups were decreased compared to before treatment(P＜0.05),and the above indicators were lower in combined group(P＜0.05).The maximum blood flow velocity was increased in both groups compared with that before treatment(P＜0.05),and the velocity in combined group was faster(P＜0.05),and pulsatility index and resistance index were reduced compared to before treatment(P＜0.05),and the combined group had lower pulsatility index and resistance index(P＜0.05).Conclusion:DNG combined with Guizhi Fuling capsule is more effective than DNG alone in treating EMT,and it can re-duce the levels of serum PAF and TGF-β1,effectively inhibit the inflammatory response,improve the uterine blood flow,control the dis-ease condition and slow down the disease process.