Objective:To investigate the clinical efficacy of eperisone combined with imrecoxib in patients undergoing arthro-scopic anterior cruciate ligament reconstruction.Methods:120 patients with anterior cruciate ligament injur were divided into a control group and an observation group according to the different treatment approaches,with 60 cases in each group.All patients underwent ar-throscopic anterior cruciate ligament reconstruction.Post-operatively,the control group was treated with imrecoxib,while the observation group received eperisone in addition to the control group's treatment.Both groups continued their respective treatments for 1 month.The treatment efficiency,first time out of bed,hospitalization time,first time to bend the knee at 90°,pain level,inflammation and knee func-tion of the two groups were recorded and compared.Results:The effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).The levels of first time out of bed,length of hospitalization and time to first 90° knee flexion were low-er in the observation group than in the control group(P＜0.05).Visual Analogue Scale(VAS)scores in both groups decreased at 1,3,and 6 months post-operation compared to pre-treatment levels(P＜0.05),and the observation group was lower than the control group(P＜0.05).Post-treatment levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)decreased in both groups,with lower levels observed in the observation group compared to the control group(P＜0.05).In-ternational Knee Documentation Committee(IKDC)subjective scores,Lysholm knee scores,and Tegner activity scores increased in both groups after treatment,with higher scores recorded in the observation group compared to the control group(P＜0.05).Conclu-sion:Treatment with eperisone in combination with imrecoxib promotes postoperative recovery in patients undergoing arthroscopic anteri-or cruciate ligament reconstruction,facilitates the relief of joint pain,helps to reduce the inflammatory response and improves the func-tion of the knee joint,and is recommended for clinical use.