Objective:To investigate the effects of dextromethorphan guaifenesin syrup combined with azithromycin on myocardi-al enzymes,coagulation function,and inflammation in children with mycoplasma pneumoniae pneumonia.Methods:88 children with my-coplasma pneumonia were divided into a control group and a combination group according to different treatment methods,with 44 cases in each group.The control group received treatment with azithromycin,while the combination group was treated with dextromethorphan guaifenesin syrup in conjunction with azithromycin,with both groups undergoing treatment for 7 days.The clinical symptom relief be-tween the two groups of children after treatment,as well as the levels of myocardial enzyme spectrum and liver function[lactate dehy-drogenase(LDH),creatine kinase(CK),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],coagulation function[D-dimer(D-D)and fibrinogen(Fbg)],and inflammatory indicators[C-reactive protein(CRP),procalcitonin(PCT),neutrophil percentage(NEU),white blood cells(WBC),and platelets(PLT)],along with the treatment efficacy and occurrence of adverse reac-tions were compared between the two groups.Results:The time for the resolution of cough,fever,and lung moist rales in the combined treatment group was shorter than that in the control group(P＜0.05).After treatment,the levels of LDH,CK,AST,and ALT,as well as D-D and Fbg levels,and the levels of CRP,PCT,NEU,WBC,and PLT in both groups of children decreased compared to before treat-ment,with the decrease in the combined treatment group being more pronounced than that in the control group(P＜0.05).The de-crease of Fbg in the combined group was greater than that in the control group,but the difference was not statistically significant(P＞0.05).The treatment efficiency of the combined group was higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups of children compared to each other(P＞0.05).Conclusion:The combination of dextromethorphan guaifenesin and azithromycin has shown significant efficacy in treating children with Mycoplasma pneumonia.It can effectively alleviate clinical symptoms,reduce myocardial damage and liver function injury,improve coagulation func-tion,and suppress inflammatory responses,while also demonstrating a high level of safety,making it worthy of clinical promotion and application.