Objective:To explore the risk factors of multi-drug resistant Pseudomonas aeruginosa(MDRPA)infection in diabet-ic foot ulcer(DFU),and to analyze the prognosis status.Methods:296 DFU patients were selected as the study objects,and 99 patients with PA infection(197 patients without PA infection)were divided into MDRPA group(n=54)and non-MDRPA group(n=45)ac-cording to the results of bacterial culture and drug susceptibility test.Univariate analysis and Logistic multivariate analysis were per-formed to analyze the risk factors of MDRPA in patients with DFU,and the prognosis of the two groups was compared.Results:Among 296 patients,320 strains of pathogenic bacteria were cultured,mainly 163 strains of Gram-negative bacteria(50.94％).The drug re-sistance rates of MDRPA to cephalosporins such as ceftazidime,cefepime,piperacillin/tazobactam and ciprofloxacin were＞80％,and the drug resistance rate to levofloxacin was＜70％.The body mass index,proportions of peripheral neuropathy,peripheral vascular dis-ease and osteomyelitis,antibacterial drug type and use time of antibacterial drug in MDRPA group were higher than those in non-MDR-PA group(P＜0.05).Osteomyelitis,hospitalization history of the same ulcer before admission,antibacterial drug type,use time of anti-bacterial drug and Wagner grading were risk factors for MDRPA infection in DFU patients(P＜0.05).Compared with non-MDRPA group,MDRPA group had lower cure rate(P＜0.05)and higher amputation/toe rate(P＜0.05).Conclusion:The main pathogenic bacteria of MDRPA infection in DFU patients is Pseudomonas aeruginosa,which has certain resistance to common antibacterial drugs.The main risk factors for MDRPA infection in DFU patients are osteomyelitis,hospitalization history of the same ulcer before admission,type of antibiotics,duration of antibiotic use and Wagner grade.The prognosis of MDRPA patients is poor.