Objective:To explore the therapeutic effect of transnasal endoscopic sinus opening on patients with chronic sinusitis and nasal polyps and analyze the related factors affecting the recovery of operative cavity mucosa membrane.Methods:Retrospective a-nalysis was performed on the data of 208 patients with chronic sinusitis and nasal polyps who received endoscopic sinus opening.The operative effect and operative cavity mucosa membrane recovery were analyzed.According to the recovery status of operative cavity mu-cosa membrane,the patients were divided into recovery group and non-recovery group,and the independent risk factors affecting the re-covery of operative cavity mucosa membrane were analyzed.Results:Among 208 patients with chronic rhinosinusitis and nasal polyps,152 cases(73.08％)were cured,34 cases(16.35％)were improved,22 cases(10.58％)were ineffective.6 months after operation,152 cases of nasal mucosa were completely restored to normal,56 cases were not completely restored to normal.The proportions of clini-cal type Ⅱ-Ⅲ,nasal mucosa injury after trimming nose hair and asthma,VAS score,Lund-Mackay score,Lund-Kennedy score,peripher-al blood EOS and tissue EOS in incomplete normal recovery group were higher than those in complete normal recovery group(P＜0.05)while the proportions of postoperative regular nasal irrigation and postoperative regular use of hormones were lower than those in complete normal recovery group(P＜0.05).Logistic regression analysis showed that clinical typing,VAS score,Lund-Mackay score,Lund-Kennedy score,tissue EOS,postoperative regular nasal irrigation and postoperative regular use of hormones were independ-ent related factors affecting the recovery of operative cavity mucosa membrane(P＜0.05).Conclusion:Transnasal endoscopic sinus o-pening is effective in the treatment of chronic sinusitis with nasal polyps.The recovery of operative cavity mucosa membrane is affected by a variety of clinical and pathological factors.And postoperative regular nasal irrigation and use of hormones help the nasal mucosa to return to normal.