Objective:To investigate the effect of combined treatment of minocycline hydrochloride and cefuroxime axetil tablets on periodontal function in patients with periodontal lesions.Methods:120 patients with pulp and periodontal lesions were divided into a control group(n=60,basic periodontal treatment+cefuroxime axetil treatment)and an observation group(n=60,control group+mi-nocycline hydrochloride)according to different intervention methods,both treated for4 weeks.The therapeutic efficacy,periodontal clin-ical indices,pain(VAS)score,gingival crevicular fluid inflammatory factors(interleukin-1 β,prostaglandin E2(PGE2),and interleu-kin-8(IL-8)],and the incidence of adverse reactions were compared between the two groups.Results:The overall response rate in the observation group was higher than that in the control group(P＜0.05).After 4 weeks of treatment,both groups exhibited a reduction in gingival bleeding index,probing depth,plaque index,VAS scores,IL-1 β,PGE2,and IL-8(P＜0.05),and the observation group was lower than the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:The combined treatment of minocycline hydrochloride and cefuroxime axetil tablets in patients with periodontal lesions is effective,can effectively improve periodontal function,relieve pain,and reduce inflammatory reactions,and is worth promoting.