Objective:To explore the influence of Shenfukang on renal function and levels of transforming growth factor-β1(TGF-β1)and connective tissue growth factor(CTGF)in patients with stage 2～4 chronic kidney disease(CKD)of spleen-kidney deficiency and stasis-toxin internal accumulation.Methods:A total of 98 patients with stage 2～4 CKD were selected,and were divided into control group(n=49)and observation group(n=49)by means of different treatment regimens.The control group was treated with conventional western medicine,whereas the observation group was added with Shenfukang granules on this basis.The observation period was 12 weeks.The renal function indexes[blood urea nitrogen(BUN),serum albumin(ALB),serum creatinine(Scr)and uric acid(UA)],blood lipids[total cholesterol(TC)and triglyceride(TG)],hemorheology indexes[whole blood high-shear viscosity(WHV),whole blood low-shear viscosity(WLV),plasma viscosity(PV)and erythrocyte aggregation index(EAI)]and serum factors(TGF-β1 and CTGF)before and after medication and clinical efficacy were compared between the two groups.Results:Compared with before medication,the levels of BUN,Scr and UA,WHV,WLV,PV and EAI,TGF-β1 and CTGF after 12 weeks of medication were re-duced in both groups(P＜0.05),and the above indexes in the observation group were lower compared with those in the control group(P＜0.05),and there were no significant differences in ALB,TC and TG levels between groups(P＞0.05).After 12 weeks of medica-tion,the total effective rate of treatment was higher in the observation group compared to the control group(91.84％vs.77.55％,P＜0.05).Conclusion:Shenfukang can protect renal function,improve hemorheology and reduce the levels of TGF-β1 and CTGF in patients with stage 2-4 CKD of spleen-kidney deficiency and stasis-toxin internal accumulation.