Objective:To investigate the effect of dexamethasone combined with ropivacaine for brachial plexus block on analge-sia in patients with distal radius fractures,and the effect on inflammatory factors.Methods:A total of 110 patients with distal radius fracture were divided into control group and observation group according to the different ways of intervention,each group was 55 cases.Both groups underwent brachial plexus block.The control group was 0.25％ropivacaine,and the observation group was dexamethasone 10 mg+0.25％ropivacaine.The liquid volume of the two groups was 20 mL.The duration of sensory block,postoperative pain score(VAS score),postoperative remedial analgesia rate,postoperative hospitalization time and adverse reactions were recorded in the two groups.The serum interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were detected.Results:Compared with the control group,the duration of sensory block in the observation group was longer(P＜0.05).The pain scores of the observation group at rest and activity at each time point from 2 to 48 h after operation were decreased(P＜0.05),and the remedial analgesia rate at 48 h after operation was lower(P＜0.05).At 24 h after operation,the serum IL-6 and TNF-α levels in the observation group was lower comparing with the control group(P＜0.05).The postoperative hospital stay in the observation group was shorter comparing with the control group(P＜0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups of patients(P＞0.05).Conclusion:Dexamethasone combined with ropivacaine for brachial plexus block can improve the postoperative analgesic effect of patients with distal radius fractures,reduce inflammatory stress,and facilitate postoperative recovery.