Objective:To explore the effectiveness and safety of bupivacaine liposome for fascia iliaca block on postoperative an-algesia in elderly patients undergoing hip surgery.Methods:90 patients were included in the research subjects,and were divided into group A(n=30),group B(n=30),and group C(n=30)according to intervention methods.Fascia iliaca block was performed in all three groups,with 0.5％lidocaine given in group A,0.25％bupivacaine hydrochloride given in group B,and bupivacaine liposome(266 mg)given in group C.The systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),pain score(NRS)and pain factors[substance P(SP),prostaglandin E2(PGE2),serotonin(5-HT)]were compared at different time points,and the ad-verse reactions were recorded.Results:The analgesic pump compression frequency and dosage of opioids were lower in groups B and C than those in group A(P＜0.05).The SBP,DBP and HR in the three groups 10 min after anesthesia were reduced compared with those before anesthesia(T0),and the group C had higher DBP than group A(P＜0.05).At 15 min(T2)and 30 min(T3)after an-esthesia,the group C had higher SBP than group A(P＜0.05),and higher HR than groups A and B(P＜0.05).The NRS scores in groups B and C were lower than that in group A at different time points after surgery(P＜0.05).The levels of SP,PGE2 and 5-HT in the three groups after surgery were risen compared with those before surgery(P＜0.05).The SP and 5-HT levels in groups B and C were lower than that in group A(P＜0.05),and the PGE2 level was lower in group C than that in groups A and B(P＜0.05).The in-cidence of nausea and vomiting was lower in group C than that in groups A and B(P＜0.05).Conclusion:Fascia iliaca block with bupivacaine liposome can improve the analgesia effect and reduce the levels of pain factors in elderly patients undergoing hip surgery,and it has good safety and has certain clinical application value.