Objective:To compare the effects of transabdominal laparoscopic nephron sparing surgery(LNSS)and retroperitone-al LNSS on perioperative indicators,renal function indicators,and inflammatory factors.Methods:96 patients with renal tumors who un-derwent LNSS were selected.According to different surgical approaches,the patients were assigned to the transabdominal group(n=46,transabdominal LNSS)and the retroperitoneal group(n=50,retroperitoneal LNSS).The two groups were compared regarding perio-perative indicators,renal function levels,inflammatory factors,and tumor markers.Results:Surgery time,warm ischemia time,intraoper-ative blood loss,and hospital stay of the retroperitoneal group were shorter and less than those of the transabdominal group(P＜0.05).The levels of blood urea nitrogen(BUN)and serum creatinine(Scr)in the retroperitoneal group were lower than those in the transab-dominal group at 1 month and 3 months after surgery(P＜0.05).Serum C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in the retroperitoneal group were lower than those in the transabdominal group(P＜0.05).Serum carbohydrate antigen 50(CA50)and carcinoembryonic antigen(CEA)levels in both groups on day 3 after surgery were lower than preoperative levels(P＜0.05),but there was no significant difference between groups(P＞0.05).There was no significant difference in the total incidence of postoperative complications between groups(P＞0.05).Conclusion:Compared with transabdominal LNSS,ret-roperitoneal LNSS has advantages in shorter surgery time,warm ischemia time,hospital stay,intraoperative blood loss.It also can help to improve renal function and inflammatory factor levels in patients with renal tumors,with a similar incidence of complications of postoper-ative complications.