Objective:To describe the multi detector computed tomography(MDCT)findings of arterial occlusion of acute mes-enteric ischemia in an animal model and its correlation with the histopathological scoring system.Methods:18 New Zealand white rab-bits were divided into one control group and five ischemic groups.An acute intestinal ischemia injury model was established by ligating the rabbits'superior mesenteric artery(SMA).After ligation of the superior mesenteric artery at 0.5,1,2,4,and 6 hours,the five ische-mic groups underwent abdominal plain scan and enhanced MDCT examination,respectively.Observed the changes in imaging features of intestinal ischemic injury with prolonged ischemia time on MDCT,measured intestinal wall CT values on MDCT,and analyzed the corre-lation between intestinal wall CT values and histopathological scores of intestinal ischemic injury tissue(Park/Chiu score).Results:At the time point of ischemia no more than 2 hours(Park/Chiu score ranged from 0 to 5),absent or reduced BW enhancement,and effu-sion and dilation of bowel lumen(BL)were found on MDCT.At the time point of ischemia more than 4 hours(Park/Chiu score ranged from 4 to 7),except for the above two signs,BW thinning and pneumatosis intestinalis(PI)were found on MDCT.The attenuation val-ues at BW on the MDCT plain images(R=-0.56,95%CI:-0.77～-0.25,P=0.001),and venous phase enhanced images(R=-0.85,95%CI:-0.93～-0.71,P<0.001),and absolute enhancement values(R=-0.80,95%CI:-0.89～-0.64,P<0.001)were negatively correlated with the pathological score of intestinal ischemic injury tissue(Park/Chiu score).Conclusion:With the ischemia time prolongs and increasing Park/Chiu score,the qualitative imaging features of intestinal ischemia injury on MDCT in-crease,and the CT value of ischemic intestinal wall gradually decreases.The measurement of intestinal wall CT values and absolute en-hancement values on MDCT can be used as quantitative indicators to quantify the severity of intestinal ischemic injury.