Objective:To analyze the expressions and significances of CXC chemokine receptor 1(CXCR1),CXC chemokine ligand 8(CXCL8)and vascular endothelial growth factor(VEGF)in prostate cancer.Methods:95 patients with prostate cancer were enrolled.The cancer tissue and adjacent tissue samples were retained during radical resection.Immunohistochemistry was used to detect and compare the protein expressions of CXCR1,CXCL8 and VEGF in tissues,and the relationship between the expressions and tumor clinicopathology was analyzed.At 2 years of follow-up after surgery,the protein expressions of CXCR1,CXCL8 and VEGF in cancer tis-sues were compared among patients with different prognosis conditions.Kaplan-Meier method was used to analyze the relationship be-tween each protein expression and prognosis.Results:The protein positive expression rates of CXCR1,CXCL8 and VEGF in cancer tis-sues and death group were higher than those in adjacent tissues and survival group(P<0.05),respectively.The positive expression rates of CXCR1,CXCL8 and VEGF proteins in cancer tissues were correlated with differentiation degree,depth of invasion and TNM staging(P<0.05).At 2 years after surgery,the average overall survival time of patients with positive expressions of CXCR1,CXCL8 and VEGF in cancer tissues was lower than that of patients with negative expressions(P<0.05).Conclusion:The positive expres-sions of CXCR1,CXCL8 and VEGF are related to the occurrence and prognosis of prostate cancer,and they can be used for the diagno-sis and prognosis evaluation of prostate cancer.