Objective:To analyze the effects of retinal laser photocoagulation combined with Ranibizumab on optic disc parame-ters in patients with moderate diabetic macular edema(DME).Methods:110 DME patients were divided into a control group and a combined group based on different treatment protocols,with 55 cases in each group.The control group received retinal laser photocoagu-lation therapy,while the combined group received additional ranibizumab treatment on the basis of the control group.The clinical effica-cy,central macular thickness,visual acuity levels,and optic disc parameters before treatment and 3 months after treatment were com-pared between the two groups.Results:The combined group had an effective rate of 80.00%,which was higher than the control group's 58.18%(P<0.05).After 3 months of treatment,both groups showed improvements in central foveal retinal thickness and visual acui-ty levels(P<0.05),with the combined group performing better than the control group(P<0.05).After3 months of treatment,there were no significant differences in optic disc area and RPC blood flow density between the two groups(P＞0.05).The combined group had a larger disc margin area compared to the control group(P<0.05),and lower optic disc volume,mean cup/disc(C/D)ratio,ver-tical cup/disc(C/D)ratio,and average RNFL thickness compared to the control group(P<0.05).Conclusion:Retinal laser photo-coagulation combined with ranibizumab can be effectively applied in the treatment of moderate DME,which can effectively improve the patient's visual acuity and optic disc parameters.