Objective:To observe serum C-reactive protein(CRP),amyloid A(SAA)and routine inflammatory parameters[neutrophil/lymphocyte ratio(NLR),systemic inflammatory response index(SIRI)]in children with influenza A,and to analyze the diagnostic value of the above indexes in children with influenza A.Methods:The clinical data of 219 cases of children with influenza A(observation group)were collected retrospectively,and 220 cases of children with non-influenza A admitted in the same hospital were selected as control group.The baseline data with the laboratory indexes of serum CRP,SAA,NLR,and SIRI,and analyzed the diagnostic value of these indexes in the infants with influenza A were compared between the two groups.Results:There was no significant differ-ence in verage body temperature at admission,gender,and WBC between the two groups(P＞0.05).Serum CRP and SAA concentra-tions as well as NLR and SIRI parameters of children in the observation group were higher than those in the control group(P<0.05).Logistic regression model was established,and the results showed that the expression of serum CRP,SAA,NLR,and SIRI was related to the children's development of influenza A,and the high expression of serum CRP,SAA,NLR,and SIRI may be a risk factor for the children's development of influenza A(P<0.05).The results of ROC curves showed that the AUCs of NLR,SIRI,CRP,and SAA for predicting the development of influenza A in children were more than 0.70,and the predictive efficacies of serum CRP(AUC=0.933,95%CI:0.905～0.951)and serum SAA(AUC=0.922,95%CI:0.901～0.948)were particularly favorable.And when predicting jointly,the AUC was 0.968(95%CI:0.946～0.980),which had significantly better diagnostic performance than the single items.Conclusion:CRP,SAA,NLR and SIRI have certain diagnostic value in children's influenza A.The combined detection of the four inde-xes can assist in the early diagnosis of influenza A in children,and is worthy of clincal promotion.