Objective:To analyze the correlation between serum Irisin and microinflammatory state in non-dialysis patients with chronic kidney disease(CKD).Methods:146 patients in non-dialysis CKD group(102 cases in microinflammation group and 44 cases in non-inflammation group)and 68 subjects in healthy control group were included.The baseline data,inflammatory indicators and ser-um Irisin between groups and the differences in inflammatory indicators and serum Irisin under different microinflammatory states were analyzed.The correlation of serum Irisin with serum albumin(Alb),retinol binding protein(RBP),serum ferritin(SF),C-reactive protein(hs-CRP)and interleukin-6(IL-6)and the diagnostic value of serum Irisin level on microinflammatory state were analyzed.Results:The serum RBP,SF,hs-CRP and IL-6 changes in the non-dialysis CKD group was higher than those in the control group(P<0.05),and the microinflammatory group was higher than the non-inflammatory group(P<0.05).For serum Alb and Irisin levels,the non-dialysis CKD group was lower than the control group(P<0.05),and the microinflammatory group was lower than the non-inflam-matory group(P<0.05).Serum Irisin was negatively correlated with serum RBP,SF,hs-CRP and IL-6(r=-0.502,-0.634,-0.667,-0.689,P<0.05),and was positively correlated with serum Alb(r=0.613,P<0.05).The sensitivity and specificity of serum Irisin in diagnosing microinflammatory state were 91.18%and 79.55%,respectively.Conclusion:Serum Irisin level is negative-ly correlated with serum RBP,SF,hs-CRP and IL-6 levels,and is positively correlated with serum Alb level in non-dialysis CKD pa-tients,and it has diagnostic value on differentiating microinflammatory state.