Objective:To study the correlation between bone metabolism markers and clinical features of patients with multiple myeloma(MM)and their significance in efficacy judgment.Methods:A total of 112 MM patients were included as the study subjects,and the relevant data of clinical characteristics and the level of bone metabolic markers before and after treatment were collected,and the correlation between bone metabolic markers and clinical characteristics of MM patients was analyzed.The changes of bone metabo-lism markers in patients with different therapeutic effects were compared before and after treatment.Receiver operating characteristic curve(ROC)was drawn to evaluate the efficacy of serum P1NP,β-CTX and OCN-MID in MM patients at admission,1,2 and 4 treat-ment courses.Results:The level of β-CTX in IgD patients was higher than IgA,IgG and light chain patients,with statistically signifi-cant differences(P<0.05).The level of β-CTX in DS stage and ISS stage Ⅲ patients was higher than that in I stage and Ⅱ stage,stage Ⅱ＞stage I,the levels of P1NP and OCN-MID in stage III were lower than those in stage I and stage II.StageⅡ