Objective:To explore the application effect of Loop-button plate internal fixation in the treatment of patients with an-kle inferior tibiofibular syndesmosis injury(ATSI).Methods:82 patients with ATSI were selected and divided into control group(n=41,cortical bone screw treatment)and observation group(n=41,Loop-button plate internal fixation treatment)by different treatment regimens.The differences in therapeutic effect,perioperative indicators,bone metabolism related factors,ankle function recovery,pain degree and incidence of complications were compared between groups.Results:There was no significant difference in the total effective rate of treatment between the two groups(P＞0.05).The surgical time,hospitalization time and bone healing time in observation group were shorter than those in control group(P<0.05).The levels of osteocalcin and bone alkaline phosphatase in the two groups were risen compared with those before surgery(P<0.05),and the levels in observation group were higher(P<0.05),and the level of β-type I collagen carboxy-terminal cross-linked peptide was reduced compared to before surgery(P<0.05),and the level was lower in observation group(P<0.05).Compared with control group,the postoperative American Orthopedic Foot and Ankle Society(AOFAS)score was higher(P<0.05)while the pain score was lower in observation group(P<0.05).The incidence of complications in obser-vationgroupwas7.32%,which was lower than24.39%in control group(P<0.05).Conclusion:The application of Loop-button plate internal fixation in patients with ATSI can shorten the surgical time and hospitalization time,promote the recovery of ankle func-tion,relieve the pain degree and reduce the incidence of complications.