Objective:To explore the independent risk factors of lymphatic leakage after laparoscopic radical gastrectomy for gas-tric cancer,andto construct a nomogram prediction model for lymphatic leakage.Methods:The clinical data of 279 patients with gastric cancer who underwent laparoscopic radical resection were retrospectively analyzed.The patients were divided into lymphatic leakage group(n=28)and non-lymphatic leakage group(n=251)according to whether lymphatic leakage occurred after operation.The differences of clinical data between the two groups were compared.Logistic regression analysis was used to establish the independent risk factors of lymphatic leakage after laparoscopic radical gastrectomy for gastric cancer.The above risk factors were used to construct a nomogram prediction model for lymphatic leakage after laparoscopic radical gastrectomy for gastric cancer,and the receiver operating characteristic(ROC)curve was drawn to verify the value of the model.Results:A total of 28 cases of lymph leakage occurred in 279 patients,with an incidence of 10.04%(28/279).The proportions of age≥60,preoperative neoadjuvant chemotherapy,tumor located in the cardia,T stage 3～4,combined organ resection,extended lymph node dissection(D2+)and non-use of somatostatin in the lym-phatic leakage group were higher than those in the non-lymphatic leakage group(P<0.05).The preoperative hemoglobin,postopera-tive hemoglobin and postoperative albumin levels in the lymphatic leakage group were lower than those in the non-lymphatic leakage group(P<0.05),and the operation time and the first anal exhaust time were longer than those in the non-lymphatic leakage group(P<0.05).Multivariate Logistic regression analysis showed that tumor located in the cardia,T stage 3～4,combined organ resection,extended lymph node dissection(D2+),low postoperative hemoglobin,low postoperative albumin and no use of somatostatin were inde-pendent risk factors for lymphatic leakage in patients undergoing laparoscopic radical gastrectomy(P<0.05).The area under the ROC curve(AUC)of the nomogram prediction model was 0.897(95%CI:0.864～0.924),and the sensitivity and specificity were 85.71%and 80.87%,respectively.Conclusion:Tumor located in the cardia,T stage 3～4,combined organ resection,extended lymph node dissection(D2+),low postoperative hemoglobin,low postoperative albumin and no use of somatostatin are closely related to the occur-rence of lymphatic leakage in patients undergoing laparoscopic radical gastrectomy.The nomogram prediction model based on the above factors can be used as an effective tool for clinical evaluation of lymphatic leakage after laparoscopic radical gastrectomy.