Objective:To investigate the influence of transvaginal cervical cerclage during pregnancy on maternal-infant out-comes under different anesthesia conditions.Methods:Patients with cervical incompetence(CIC)who underwent McDonald's surgery were selected as the research subjects,71 patients were selected from the anesthesia state and included in the anesthesia group,and 113 patients were selected from the non-anesthesia state and included in the non anesthesia group.Each group was selected based on cervi-cal length≥10 mm and＜10 mm for data analysis.The differences in surgical related indicators,maternal complications,pregnancy outcomes,and neonatal outcomes were recorded.Results:For patients with cervical length＜10 mm,the non anesthesia group had lower hospitalization costs than the anesthesia group(P＜0.05),shorter surgical time than the anesthesia group(P＜0.05),and greater neonatal body weight than the anesthesia group(P＜0.05).For patients with cervical length≥10 mm,the non anesthesia group had a shorter surgical time than the anesthesia group(P＜0.05),a higher rate of vaginal delivery than the anesthesia group(P＜0.05),a lower rate of premature delivery than the anesthesia group(P＜0.05),and a lower rate of transferring to NICU after delivery than the anesthesia group(P＜0.05).Conclusion:For patients undergoing McDonald surgery,non-anesthesia state has certain advantages,and can shorten the surgical time,reduce the expense,and help to reduce the incidence rate of premature birth and improve the neonatal out-comes.