Objective:Combination therapy with percutaneous endoscopic foraminal approach for discectomy,core muscle train-ing,The treatment effect in patients with lumbar intervertebral disc herniation was analyzed.Methods:108 patients with lumbar disc herniation were selected and divided into control group and study group according to different treatment methods,54 cases in each group.The control group underwent discectomy,and the study group underwent core muscle training after surgery.The pain level,pain mediators,inflammatory factor level,lower limb nerve conduction function,lumbar spine function,and clinical efficacy were tested and compared.Results:Compared with the preoperative period,the visual analogue scale(VAS),low back pain ODI scale The Oswestry Disability Index(ODI),5-hydroxytryptamine(5-HT),prostaglandin E2(PGE2),tumor necrosis factor ɑ(TNF-ɑ),interleukin 6(IL-6),and high-sensitivity C-reactive protein(hs-CRP)levels were reduced at 1,3,and 6 months postoperatively,and the study group was lower than the control group(P＜0.05).Compared with the preoperative period,β-endorphin(β-EP)levels,lower limb nerve conduction velocity,and JOA scores(Japanese Orthopaedic Association Scores JOA)were elevated at 1,3,and 6 months postoperative-ly,and the study group was higher than the control group(P＜0.05).The total effective rate of treatment in the study group was higher than that in the control group(P＜0.05).Conclusion:For patients with lumbar disc herniation,percutaneous endoscopic foraminal ap-proach combined with core muscle training can promote the recovery of lumbar function and reduce the degree of pain,and the clinical effect is good.