Objective:To analyze the clinical efficacy of Edaravone combined with teneplase in the treatment of vascular demen-tia(VD)after cute ischemic cerebral infarction(AICI).Methods:A total of 210 patients with AD after AICI were included in this study,and were divided into the experimental group and the control group according to different treatment methods,with 105 cases in each group.Both groups received conventional treatment after admission,while the control group received teneplase thrombolytic therapy in the conventional treatment.Based on the experimental group in the control group used the adr in intravenous drip treatment.After 4 weeks of treatment,the clinical efficacy,cognitive function[Mini Mental State Examination(MMSE)and Montreal Cognitive Assess-ment(MoCA)scores],neurological function[National Institutes of Health Stroke Scale(NIHSS)],daily living ability(ADL scores)and related laboratory indexes[levels of vascular endothelial growth factor(VEGF)and hypoxia inducible factor-1α(HIF-1α)]of the two groups were compared.Results:The total effective rate in experimental group was higher than that in the control group(95.24%vs.81.90%,P＜0.05).After 4 weeks of treatment,MMSE,MoCA,VEGF,HIF-1α were increased in both group,and the experimental group was higher than the control group(P＜0.05).The NIHSS scores and ADL were reduced,the and the experimental group was lower than the control group(P＜0.05).Conclusion:Edaravone combined with teneplase is effective in the treatment of VD after AI-CI,which can effectively improve the cognitive and neurological functions of patients,promote vascular repair,inhibit hypoxia,and im-prove patients'ability of daily life.