Objective:To analyze the effects of different approaches of omental sac approach and intermediate approach in lapa-roscopic radical resection on inflammatory factors and stressindicatorsin patients with left colon cancer.Methods:80 patients with left-sided colon cancer scheduled for laparoscopic radical surgery were selected as the study subjects.According to different surgical approa-ches,they were divided into a study group(omental bursa approach)and a control group(intermediate approach),with 40 cases in each group.The surgical-related indicators and postoperative recovery of the two groups were compared,and serum inflammatory factors and stress indicators were measured preoperatively and on the third postoperative day.Results:There were no statistically significant differences in surgical time and number of lymph nodes dissected between the two groups(P>0.05),but the study group had lower laparoscopic free time and postoperative drainage volume compared to the control group(P＜0.05).There were no statistically signifi-cant differences in first exhaust time,first defecation time,and feeding time between the two groups(P>0.05),but the study group had a shorter hospital stay compared to the control group(P＜0.05).There were no statistically significant differences in inflammatory factors and stress levels before surgery between the two groups(P>0.05),and the levels of hs-CRP,IL-6,TNF-α,norepinephrine,epi-nephrine,and cortisol in both groups were higher after surgery compared to before surgery(P＜0.05),and the study group was lower than the control group(P＜0.05).Conclusion:Laparoscopic radical surgery with different approaches has different effects on patients with left colon cancer.Compared with the middle approach,omental sac approach can effectively shorten the laparoscopic free time and hospital stay of patients,and has less impact on inflammatory factors and stressindicatorsof patients,which is conducive to early postop-erative rehabilitation of patients.