Objective:To explore the clinical value of microscopic clipping and endovascular interventional embolization in the treatment of cerebral aneurysms.Methods:A retrospective analysis was conducted on the clinical data of 90 patients with cerebral aneu-rysms.The patients were divided into clipping group and intervention group according to different surgical techniques,with 45 cases in each group.The perioperative indexes,vascular endothelial function and inflammatory factors before surgery and at 1 week after surgery,nerve function[National Institutes of Health Stroke Scale(NIHSS),Glasgow Outcome Scale(GOS)]at 6 months after surgery in the two groups were compared.Results:The perioperative indexes in intervention group were lower than those in clipping group(P＜0.05).At 1 week after surgery,levels of VEGF and ET-1 in intervention group were lower than those in clipping group(P＜0.05),while CGRP was higher than that in clipping group(P＜0.05).At 1 week after surgery,levels of MMP-9,TNF-α and HIF-1α in inter-vention group were lower than those in clipping group(P＜0.05).At6 months after surgery,NIHSS score in intervention group was lower than that in clipping group,while GOS score was higher than that in clipping group(P＜0.05).Conclusion:Endovascular inter-ventional embolization has advantages such as simple operation and fast postoperative recovery,which can effectively repair vascular and cerebral nerve injury,and reduce inflammatory response in patients with cerebral aneurysms.