Objective:To explore the effects of external counterpulsation(ECP)therapy combined with exercise intervention on cardiac function,exercise tolerance and negative sentiment in senile patients with coronary heart disease after percutaneous coronary in-tervention(PCI).Methods:110 senile patients with coronary heart disease who underwent PCI were divided into single exercise group(n=55)and combined ECP group(n=55)according to the different intervention methods.Both groups received routine intervention after PCI,on this basis,the single exercise group received exercise intervention,and the combined ECP group received ECP combined exercise intervention,all for 3 months.The levels of cardiac function[left ventricular ejection fraction(LVEF),maximum heart rate(HRmax),cardiac output(CO)],physical endurance[peak oxygen uptake(Peak VO2),perceived fatigue scale(RPE),6-minute walking distance(6-MWD)],Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)and quality of life questionnaire(SF-36)were compared between the two groups before and after intervention.Results:The LVEF,HRmax,CO,Peak VO2,6-MWD and SF-36 scores of the combined ECP group after intervention were higher than those of the single exercise group(P＜0.05).The scores of RPE,HAMA and HAMD in the combined ECP group were lower than those in the single exercise group(P＜0.05).Conclusion:ECP therapy combined with exercise intervention can improve the cardiac function and physical endurance of senile patients with coro-nary heart disease after PCI,relieve anxiety and depression,and improve the quality of life.