Objective:To analyze the clinical efficacy of laparoscopy with choledochoscopy for lithotomy+primary duct closure(PDC)on elderly common bile duct stones(CBDS)with gallbladder stones.Methods:102 elderly patients with CBDS and gallbladder stones in the hospital were retrospectively collected.According to different treatment regimens,the enrolled patients were divided into group A(laparoscopy with choledochoscopy for lithotomy+PDC therapy,n=51)and group B(laparoscopy with choledochoscopy for lithotomy+T tube drainage,n=51).The surgery-related indicators,liver function and inflammatory stress indicators at 72 h after sur-gery were compared between groups of patients,and the incidence rates of complications and postoperative review conditions were recor-ded in the two groups of patients.Results:The surgical time,anal exhaust time and hospital stay in the group A were shorter than those in the group B(P＜0.05),and the total hospitalization cost was less than that in the group B(P＜0.05).The levels of ALP and TBIL in both groups were lower at 72 h after surgery than those before surgery(P＜0.05)while the levels of IL-6,CRP,E and Cor were higher than those before surgery(P＜0.05),but the levels of the above indicators were lower in the group A than those in the group B(P＜0.05).There were no statistical differences in the total incidence rate of complications and postoperative review conditions be-tween the two groups(P＞0.05).Conclusion:The long-term effects of PDC and T tube drainage during laparoscopy with choledochos-copy for lithotomy are similar in the treatment of elderly CBDS with gallbladder stones,but PDC has more advantages in shortening sur-gical time and hospital stay,promoting postoperative recovery and improving liver function and inflammatory stress response.