Objective:To explore the relationship of rate pressure product(RPP)changes with coronary artery lesion degree and lesion count in patients with coronary heart disease.Methods:83 patients with coronary heart disease were selected as the coronary heart disease group,and they were divided into mild group(n=48)and severe group(n=35)according to the degree of lesions.Ac-cording to the number of lesions,they were divided into single vessel lesion group(n=43)and multi vessel lesion group(n=40).An-other 50 volunteers who underwent health check ups during the same period were selected as the control group.The differences in heart rate(HR),systolic blood pressure(SBP),and RPP were compared between coronary heart disease group and control group.The static RPP and dynamic peak RPP of patients with different degrees and numbers of coronary artery lesions were compared.Receiver operating characteristic(ROC)analysis was used to assess the predictive efficacy of RPP for different degrees and numbers of lesions.Results:The static RPP and dynamic peak RPP in the coronary heart disease group were higher than those in the control group(P＜0.05).The static RPP and dynamic peak RPP of the mild group were lower than those of the severe group(P＜0.05).ROC curve analysis showed that the sensitivity,specificity,and AUC of static RPP and dynamic peak RPP for patients with different degrees of coronary artery dis-ease were 77.14％,66.67％,0.768,and 74.29％,93.75％,and 0.869,respectively.The sensitivity,specificity,and AUC of static RPP and dynamic RPP for patients with different numbers of coronary artery lesions were 71.59％,97.50％,0.673 and 100.00％,23.26％,0.726,respectively.Conclusion:The RPP in patients with coronary heart disease is increased during the exercise test,,and it is closely related to coronary artery lesion degree and lesion count.