Objective:To evaluate the clinical efficacy of sirolimus-eluting stents in conjunction with low molecular weight hepa-rin for the interventional treatment of coronary heart disease(CHD)in elderly patients,and to assess both short-term and long-term out-comes following a 12-month follow-up period.Methods:A total of 114 elderly patients with coronary heart disease(CHD)who under-went percutaneous coronary intervention(PCI)were divided into a control group(n=57)and an experimental group(n=57)based on differing treatment protocols.Patients in the control group received sirolimus-eluting stents during PCI,while those in the experimen-tal group received low molecular weight heparin in addition to the standard treatment regimen.Throughout the study period,cardiac function indices,coronary perfusion recovery,and myocardial marker levels were systematically recorded for both groups.Additionally,subjects were followed up for 12 months to evaluate both short-term and long-term prognostic outcomes.Results:After treatment,the levels of left ventricular ejection fraction(LVEF),maximum oxygen uptake(VO2max),and 6-minute walk test(6MWT)in both groups exhibited improvements compared to pre-treatment values.Furthermore,the study group demonstrated greater improvement than the con-trol group(P＜0.05).After 24 hours of treatment,there was no occurrence of the no-reflow phenomenon in either group.The study group exhibited a higher proportion of TIMI blood flow grade 3 compared to the control group,while experiencing lower incidences of slow blood flow and CTFC(P＜0.05).After treatment,the levels of serum Myoglobin(MYO),Creatine Kinase-MB(CK-MB),and Cardiac Troponin(cTn)in both groups exhibited a decrease compared to pre-treatment levels,with the study group demonstrating a greater reduction than the control group(P＜0.05).There was no significant disparity observed in the proportion of patients with poor short-term prognosis between the two groups(P＞0.05).The study group exhibited a lower rate of poor long-term prognosis at 10.53％,compared to 28.07％ in the control group,which was found to be statistically significant(P＜0.05).Conclusion:The com-bination of sirolimus-eluting stents and low molecular weight heparin demonstrates superior efficacy in the interventional treatment of CHD in elderly patients,enhances long-term prognosis,and exhibits clinical application value.