Objective:To explore the efficacy of simvastatin combined with acetylcysteine in the treatment of Bronchial Asthma(BA)and the effect on airway inflammation in patients.Methods:A retrospective analysis of clinical date was conducted on 122 BA patients,who were divided into the experimental group and the control group according to different treatment methods,with 61 cases in each group.The control group received routine treatment and took N-acetylcysteine tablets at the same time,while the experimental group received simvastatin tablets on the basis of the control group.The therapeutic effects,serological indexes[hypersensitive C-reac-tive protein(hs-CRP),Interleukin-6(IL-6)and Eosinophils(EOS)],airway inflammation indicators[Fractional exhaled nitric oxide(FeNO),Alveolar nitric oxide concentration CaNO)]and Asthma Control indicators[Asthma Control Test(ACT),number of asthma attacks]after 2 months of treatment were compared between the two groups.Results:The total effective rate of 96.72％in the experi-mental group was higher than 78.69％in the control group(P＜0.05).Before treatment,there were no significant differences in sero-logical indexes,airway inflammation indexes and asthma control indexes between the two groups(P＞0.05).Compared with before treatment,serological indexes and airway inflammation indexes were decreased in both groups after treatment(P＜0.05),ACT score was increased(P＜0.05),and the number of asthma attacks was decreased(P＜0.05).After treatment,serological and airway inflam-mation indexes of the experimental group were lower than those of the control group(P＜0.05),ACT score was higher than that of the control group(P＜0.05),and the number of asthma attacks was lower than that of the control group(P＜0.05).Conclusion:Simvas-tatin combined with acetylcysteine is effective in the treatment of BA,which can effectively reduce the level of inflammation in patients,relieve airway inflammation,and help control the progression of the disease.