Objective:To explore the changes and predictive value of blood uric acid(BUA),lipid metabolism and vitamin D in elderly patients with spinal degenerative changes complicated with osteoporosis.Methods:Retrospective analysis was performed on 112 elderly inpatients with spinal degenerative changes in the hospital.54 patients with osteoporosis were included in group A and 58 pa-tients without osteoporosis were enrolled as group B.The differences in BUA,lipid metabolism[total cholesterol (TC),triglyceride(TG),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol(LDL-C)]and 25-hydroxyvitamin D[25(OH)D]in the two groups were observed.Receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of the above indicators on elderly spinal degenerative changes with osteoporosis.Results:Compared with group B,the levels of BUA,TC,TG and LDL-C in group A were higher,while the levels of HDL-C and 25(OH)D were lower(P＜0.05).ROC curve analysis showed that the areas under the ROC curves (AUCs)of BUA,TC,TG,HDL-C,LDL-C and 25(OH)D were 0.876,0.792,0.770,0.880,0.797 and 0.917,respectively.Conclusion:Serum BUA,TC,TG and LDL-C in elderly patients with spinal degenerative changes and osteoporosis are at high levels while HDL-C and 25(OH)D are at low levels.The above indicators have certain predictive value on eld-erly spinal degenerative changes with osteoporosis.