Objective:To explore the curative effect of Bushen Huoxue decoction combined with chitosan injection on patients with knee osteoarthritis(KOA)after arthroscopic surgery.Methods:A total of 116 patients with KOA were divided into control group and observation group according to different postoperative intervention schemes,with 58 cases in each group.Both groups underwent ar-throscopic debridement,after operation,the control group was treated with intra-articular injection of chitosan,and the observation group was treated with Bushen Huoxue Decoction combined with intra-articular injection of chitosan for 4 weeks.The efficacy,pain score,knee swelling value,knee function[knee flexion,osteoarthritis index scale (WOMAC),Lysholm score],ultrasound indexes of knee joint[joint effusion thickness,synovial thickness]and serum inflammatory factors[interleukin-6(IL-6),interleukin-1 β(IL-1β),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results:After 4 weeks of treatment,compared with the control group,the total effective rate of the observation group was higher(P＜0.05).Compared with the control group,the VAS score,swelling value,WOMAC score and joint effusion thickness,synovial thickness in the observation group were lower(P＜0.05),and the knee flexion and Lysholm score were higher(P＜0.05).The levels of serum IL-6,IL-1 β and TNF-α in the observation group were lower than those in the control group(P＜0.05).Conclusion:Bushen Huoxue Decoction combined with chitosan injection can improve the curative effect after KOA operation,promote pain relief and knee joint function recovery,reduce inflammation.