Objective:To explore the application effects of low-temperature plasma radiofrequency ablation combined with ozone and collagenase in patients with cervical disc herniation.Methods:A total of 90 patients with cervical disc herniation who were treated were selected and divided into a study group and a control group according to different treatment methods,with 45 cases in each group.The study group received treatment using low-temperature plasma radiofrequency ablation combined with ozone and collagenase,while the control group was treated with low-temperature plasma radiofrequency ablation combined with ozone.The Visual Analogue Scale(VAS)scores before and after surgery were compared between the two groups.The Japanese Orthopaedic Association(JOA)scale was used to evaluate cervical vertebra function in patients before and after surgery,and the excellent rate of the treatments between the two groups was compared.Results:All patients completed at least 6 months of follow-up.There were no statistically significant differences in VAS and JOA scores between the two groups before surgery and at 1 month post-surgery(P＞0.05).At 3 and 6 months post-surger-y,the VAS and JOA scores in the study group were better than those in the control group(P＜0.05).At 6 months post-surgery,the ex-cellent treatment rate in the study group was 93.33％,which was higher than the 75.56％in the control group(P＜0.05).Conclu-sion:The combination of low-temperature plasma radiofrequency ablation with ozone and collagenase for the treatment of patients with cervical disc herniation can enhance the treatment effectiveness,yielding better results than low-temperature plasma radiofrequency ab-lation combined with ozone injection alone.