Objective:To investigate the efficacy and prognosis of concurrent radiochemotherapy in locally advanced esophageal cancer,and analyze the influencing factors.Methods:A total of 120 patients with locally advanced esophageal cancer who underwent concurrent radiochemotherapy were selected.The short-term efficacy and long-term prognosis of concurrent radiochemotherapy were e-valuated.Logistic regression analysis was used to explore factors influencing short-term efficacy.Kaplan-Meier survival analysis and COX regression analysis were used to explore factors influencing long-term prognosis.Results:There was complete remission in 23 cases(19.17％),partial remission in 64 cases(53.33％).The objective remission rate was 72.50％.Logistic regression analysis showed that proportions of T4 stage,lymph node metastasis and well differentiation in the non-remission group were higher than those in the re-mission group(P＜0.05).T4 stage(OR:3.337,95％CI:1.308～8.515),lymph node metastasis(OR:4.216,95％ CI:1.457～12.199)and well differentiation(OR:5.772,95％ CI:2.162～15.409)were risk factors for no remission after concurrent radioche-motherapy(P＜0.05).The patients were followed up for 5.8～60.0 months,with a median follow-up period of 37.4 months,73 pa-tients(60.83％)died and 47 patients(39.17％)survived.Kaplan-Meier survival analysis showed that T3 stage(44.23％)was higher than T4 stage(17.96％),and without lymph node metastasis(58.76％)was higher than lymph node metastasis(16.99％).The cumulative survival rate of patients with high differentiation(51.37％),moderate differentiation(22.06％),and poor differentia-tion(5.68％)decreased in order(P＜0.05).COX regression analysis showed that T4 stage(HR:2.219,95％CI:1.142～4.312),lymph node metastasis(HR:2.809,95％CI:1.246～6.337),and poor differentiation(HR:3.360,95％ CI:1.458～7.744)were risk factors for poor prognosis in patients with locally advanced esophageal cancer(P＜0.05).Conclusion:Concurrent radiochemother-apy is an effective method for treating locally advanced esophageal cancer.T staging,lymph node metastasis status and differentiation degree are influencing factors on the efficacy of concurrent radiochemotherapy.T4 stage,lymph node metastasis and poor differentiation are more likely to lead to poor prognosis.