Objective:To explore the effect of spiritual care intervention on psychological resilience,anxiety and depression,fear of disease progression and quality of life in patients with cervical cancer after operation.Methods:A total of 156 patients with cervical cancer who underwent surgical treatment were divided into control group(n=78)and observation group(n=78)according to differ-ent nursing methods.The control group received routine nursing after operation,and the observation group received spiritual care after operation.Both groups were intervened for 6 weeks.The changes of psychological resilience[Connor-Davidson Resilience Scale(CD-RISC)],anxiety and depression levels[Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)],fear of disease pro-gression[Fear of Disease Progression Scale(FoP-Q-SF)]and quality of life[Cervical Cancer Quality of Life Scale(FACT-Cx)]were compared between the two groups before and after intervention.Results:After intervention,the total score of CD-RISC and the scores of each dimension in the two groups increased(P＜0.05),and those in the observation group were higher(P＜0.05).The scores of SAS and SDS in the two groups decreased(P＜0.05),and those in the observation group were lower(P＜0.05).After intervention,the FoP-Q-SF scores of the two groups decreased(P＜0.05),and the observation group was lower(P＜0.05).The total score of FACT-Cx and the scores of each dimension in the two groups increased(P＜0.05),and those in the observation group were higher(P＜0.05).Conclusion:Spiritual care intervention can effectively improve the psychological resilience of patients after cervical cancer surgery,re-duce anxiety,depression and fear of disease progression,and improve the quality of life.