Objective:To explore clinical curative effect of pidotimod combined with pulmicort and its influences on immuno-globulins and T lymphocytes in children with recurrent respiratory tract infections(RRTIs).Methods:According to different therapeu-tic regimens,80 children with RRTIs were divided into control group(n=40,pulmicort)and observation group(n=40,pidotimod combined with pulmicort).All children were treated for 2 months.The curative effect after treatment and remission time of symptoms(cough remission,disappearance of red throat and lung rale,fever duration)during treatment in the two groups were compared.The lev-els of immunoglobulins(IgA,IgG,IgM)and T lymphocyte subsets(CD3+T cells,CD4+T cells,CD8+T cells)before and after treat-ment,and disease recurrence within 6 months of follow-up in the two groups were recorded.Results:Compared with control group,total response rate of treatment was higher in observation group(P<0.05),and remission time of symptoms was shorter(P<0.05).Com-pared with control group after treatment,levels of IgA,IgG,IgM,CD3+and CD4+T cells were higher in observation group(P<0.05),and level of CD8+T cells was lower(P<0.05).Within6 months of follow-up,recurrence rate in observation group was lower than that in control group(P<0.05).Conclusion:Pidotimod combined with pulmicort can effectively improve curative effect,accelerate symp-toms remission,regulate immune function and reduce recurrence rate in children with RRTIs.