Objective:To assess the clinical value of cefazoxime and beclomethasone sequential therapy in patients with pulmo-nary fibrosis(PF)complicated by acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods:A total of 120 pa-tients with acute exacerbation of PF and COPD were divided into the conventional group(the patient received intravenous levofloxacin for anti-infection treatment in combination with systemic glucocorticoid therapy)and the study group(cefazoxime and beclomethasone sequential treatment on the basis of conventional treatment)according to different treatment methods,60 cases in each group.The clini-cal efficacy,oxygenation status,inflammatory factor levels,quality of life,short-term and long-term prognosis were compared between the two groups.Results:The total clinical efficacy of the study group was 98.33%,which was higher than 85.00%of the conventional group(P<0.05).After treatment,the improvements in arterial partial pressure of oxygen(PaO2),and oxygenation index(PaO2/FiO2)increased in both groups,and the study group was higher than the conventional group(P<0.05).Partial pressure of carbon di-oxide(PaCO2)decreased in both groups,and the study group was lower than the conventional group(P<0.05).After treatment,the levels of inflammatory factors,COPD assessment test(CAT)score and modified dyspnea scale(mMRC)score in both groups de-creased,and the study group was lower than the conventional group(P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions and recent recurrence rate between the study group and the conventional group(P>0.05).The long-term recurrence rate in the study group was 6.67%,which was lower than that of the conventional group(21.67%)(P<0.05).Conclusion:Cefazoxime combined with beclomethasone sequential therapy can significantly improve the comprehensive efficacy of pa-tients with acute exacerbation of PF-COPD,which can effectively control infection and inflammation,optimize symptoms and quality of life,and has high application value.