Objective:To explore the correlation between radiological characteristics and serum biomarker levels in patients with atrophic gastritis(AG).Methods:130 gastritis patients were selected as the subjects.Based on endoscopic and pathological biopsy re-sults,they were divided into a control group(non-atrophic gastritis patients,n=71)and an observation group(atrophic gastritis pa-tients,n=59).The observation group was further divided into mild atrophy group(n=23),moderate atrophy group(n=24),and se-vere atrophy group(n=12).The correlation between the imaging features and severity of AG and the levels of gastrin 17(G-17),pep-sinogenⅠ(PGⅠ),pepsinogen Ⅱ(PGⅡ),procalcitonin(PCT),interleukin-6(IL-6),interleukin-17(IL-17),interferon-γ(IFN-γ),tumor necrosis factor(TNF-α),and transforming growth factor β1(TGF-β1)were analyzed.Results:AG patients had increased levels of PCT,IL-6,IL-17,and TGF-β1(P<0.001),while G-17 and PG levels were decreased(P<0.001).PCT,IL-6,and TGF-β1 levels were positively correlated with the severity of AG(P<0.001),while G-17 and PG levels showed a negative correlation(P<0.001).PG Ⅰ and PCT levels were independent factors affecting the severity of AG(P<0.05).Conclusion:PCT,IL-6,IL-17,and TGF-β1 levels are positively correlated with the occurrence of AG,while G-17 and PG levels are negatively correlated.PG Ⅰ and PCT levels are independent factors affecting the severity of AG.